Allison Janney

as Sue Buttons

Mila Kunis

as Nancy

Regina Hall

as Cam Harris

Awkwafina

as Mina

Wanda Sykes

as Rita

Ellen Barkin

as Debbie

Matthew Modine

as Karl Buttons

Jimmi Simpson

as Petey Buttons

Keong Sim

as Mr. Kim

Juliette Lewis

as Gloria Michaels

Clifton Collins Jr.

as Ray

Samira Wiley

as Jonelle

Bridget Everett

as Leah Norton

T.C. Matherne

as Officer Jones

Dominic Burgess

as Captain Riggins

Chris Lowell

as Steve

Michael A. Newcomer

as Jonathan Rose

Liz Elkins Newcomer

as Robin Rose

Shannon Cogan

as Kentucky News Anchor

Cleta Elaine Ellington

as Bakery Clerk

Susan McPhail

as Sweet Elderly Motel Clerk

Lucy Faust

as Janet

CC Castillo

as Roberta

Zack Shires

as Teenage Boy

Nathan Wells

as Kentucky News Anchor #1

Cherita Brent

as Kentucky News Anchor #2

Sampley Barinaga

as Teen Asshole

Connor Hammond

as Drugged Out Teen

K. Steele

as Officer #1

Jock McKissic

as Lennie

Joseph Landry

as Camera Man

Peter Jaymes Jr.

as Tech Guy

Sylvia Grace Crim

as Make-Up Woman

Emily Russell

as Gloria's Assistant

Deneen Tyler

as Bank Manager

Alex Stage

as Lab Tech

Ryan Baughman

as Employee

Reggi Marion

as News Reporter

Virginia Patterson

as Granny Rose

Rukey Styles

as Pissed Off Detainee

Perraniqua Champ

as Employee #2

Tate Taylor

as Attractive Customer

Brian Duong

as Kentucky News Anchor #4

Aaron Mitchell

as Stanlow Police Officer (uncredited)