Yahya Abdul-Mateen II

as Anthony McCoy

Teyonah Parris

as Brianna Cartwright

Colman Domingo

as William Burke

Nathan Stewart-Jarrett

as Troy Cartwright

Kyle Kaminsky

as Grady Smith

Vanessa Williams

as Anne-Marie McCoy

Brian King

as Clive Privler

Miriam Moss

as Jerrika

Rebecca Spence

as Finley Stephens

Carl Clemons-Hopkins

as Jameson

Christiana Clark

as Danielle Harrington

Michael Hargrove

as Candyman / Sherman Fields

Rodney L Jones III

as Billy

Ireon Roach

as Trina

Breanna Lind

as Annika

Heidi Grace Engerman

as Haley Gulick

Sarah Lo

as Samantha

Ro White

as Boof

Mark Montgomery

as Detective Lipez

Torrey Hanson

as Jack Hyde

Cassie Kramer

as Librarian

Sarah Wisterman

as Celine

Cedric Mays

as Gil Cartwright

Alec Silver

as Restaurant server

Hannah Love Jones

as Young Brianna

J. Nicole Brooks

as Dr. Collins

Pamela Jones

as Reporter Devlin Sharpe

Genesis Denise Hale

as Sabrina

Katherine Purdie

as Haley's Mom

Tien Tran

as Jane Ji

Mike Geraghty

as Police Officer Jones

Aaron Crippen

as Police Officer Smith

Dan Fierro

as Police Officer Rooney

Nadia Simms

as Ringleader

Nancy Pender

as TV News Anchor

Johnny Westmoreland

as Samuel Evans

Guy Spencer

as John Crawley

Daejon Staeker

as The Kid

Tony Todd

as Candyman / Daniel Robitaille

Virginia Madsen

as Helen Lyle (voice)

Ben Marten

as Officer Cooke (uncredited)