E. G. Daily

as Tommy Pickles (Voice)

Nancy Cartwright

as Chuckie Finster (voice)

Kath Soucie

as Phil DeVille / Lil DeVille / Betty DeVille (voice)

Cheryl Chase

as Angelica Pickles (voice)

Dionne Quan

as Kimi Finster (voice)

Tara Strong

as Dil Pickles (voice)

Debbie Reynolds

as Lulu Pickles (voice)

Jim Belushi

as Santa Claus (voice)

Paul Reubens

as Hermie the Elf (voice)

Tress MacNeille

as Charlotte Pickles (voice)

Julia Kato

as Kira Finster (voice)

Melanie Chartoff

as Didi Pickles (voice)

Michael Bell

as Chas Finster / Drew Pickles (voice)