Randy Quaid

as General George S. Merlin

Brenda Epperson

as Dr. Laura Casey

Katherine Heigl

as Shannon Griffin

James Doohan

as Sheriff Carlson

George Takei

as Dr. Hiro Fujimoto

Meredith Salenger

as Veronica Hart

Ty O'Neal

as Deputy Bo

David Lipper

as Steve Williams

Bernie Kopell

as Gil Griffin

Anne Lockhart

as Cammie Griffin

Downtown Julie Brown

as Katie Cunning

Doug Jones

as Mother Bug