Sean Astin

as Randall P. McDuff / Josiah (voice)

Pamela Hayden

as Sublimity Jill / Daughter #2 (voice)

Scott Lawrence

as Lewis Clark Jefferson / Cowpoke #3 (voice)

Maurice LaMarche

as Bumpy Snits / Ferryman #1 / Cowpoke #2 (voice)

Carolyn Lawrence

as Ornery Sue / Wagonmaster's Wife / Daughter #3 (voice)

Craig Bartlett

as Romeo Jones / Ferryman #2 / Cheyenne #1 (voice)

Andrea Bowen

as Billie Bartley / Manifest Destiny (voice)

Josh Hutcherson

as Toad E. Bartley (voice)

Dan Conroy

as Wagonmaster / Pioneer #1 / Cowpoke #1 (voice)

Danny Mann

as Three-Eyed Jack / Wall-Eyed Tom (voice)

Christie Insley

as Daughter #1 (voice)

Dan Castellaneta

as Wild Bill Hickok / Clerk / Cheyenne #2 (voice)