Dove Cameron

as Gwen Stacy / Ghost-Spider (voice)

Tyler Posey

as Inferno

Cierra Ramirez

as America Chavez

Milana Vayntrub

as Squirrel Girl

Kathreen Khavari

as Kamala Khan / Ms. Marvel (voice)

Kamil McFadden

as Patriot

Sofia Wylie

as Ironheart

Dee Bradley Baker

as Tippy-Toe

Skai Jackson

as Gloria

Tara Strong

as Screaming Mimi/Mary Jane