Tyler Posey

as Inferno / Dante Pertuz (voice)

Navia Robinson

as Zayla (voice)

Cierra Ramirez

as America Chavez (voice)

Kathreen Khavari

as Kamala Khan / Ms. Marvel (voice)

Milana Vayntrub

as Squirrel Girl / Doreen Green (voice)

Dove Cameron

as Gwen Stacy / Ghost-Spider (voice)

Dee Bradley Baker

as Lockjaw / Tippy-Toe (voice)

Gary Cole

as Invisibilio (voice)

Niecy Nash

as Shocktress (voice)

Jeannie Tirado

as Gabriela / Teacher (voice)

Meera Rohit Kumbhani

as Ammi (voice)

Tony Mirrcandani

as Abu (voice)