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Cast (133)
Leonardo DiCaprio
as Dr. Randall Mindy
Jennifer Lawrence
as Kate Dibiasky
Meryl Streep
as President Orlean
Cate Blanchett
as Brie Evantee
Rob Morgan
as Dr. Teddy Oglethorpe
Jonah Hill
as Jason Orlean
Mark Rylance
as Peter Isherwell
Tyler Perry
as Jack Bremmer
Timothée Chalamet
as Yule
Ron Perlman
as Benedict Drask
Ariana Grande
as Riley Bina
Kid Cudi
as DJ Chello
Himesh Patel
as Phillip
Melanie Lynskey
as June Mindy
Michael Chiklis
as Dan Pawketty
Tomer Sisley
as Adul Grelio
Paul Guilfoyle
as General Themes
Robert Joy
as Congressman Tenant
Jack Alberts
as Oliver
T
Ting
as Win
Lance A. Williams
as Daniel
Shimali de Silva
as Nisha
Hettienne Park
as Dr. Calder
Rafael Silva
as Nasa Scientist
Lonnie Farmer
as Old Aide #1
H.S
Homa Sarabi-Daunis
as White House Office Worker
B.D
Barbara Douglass
as Office Worker
Rena Maliszewski
as Anchor Reporting On Colon
Erik Parillo
as Sherriff Conlon
R.R
Robert Hurst Radochia
as Evan Mindy
Conor Sweeney
as Marshall Mindy
Ross Partridge
as Keith Ollens
R.D
Richard Donelly
as Old Aide #2
Liev Schreiber
as Bash Narrator (voice)
Samsara Yett
as Isherwell Child Aide
Meara Mahoney Gross
as Isherwell Child Aide
J.O
Jaden Onwuakor
as Isherwell Child Aide
Staci Roberts
as Linda Dicalio
W.B
Wendy Bellevue
as Isherwell Child Handler
M.Y
Mishka Yarovoy
as Executive
Chris Everett
as Chief Editor Paula Woods
Annette Miller
as Mrs. Tanken
Stephen Thorne
as Benjamin
A.D
Aimee Doherty
as Passerby
Natalie Rebenkoff
as Talent PA
Gary Tanguay
as News Anchor #2
Georgia Lyman
as Groomer Thalia
P.D
Patricia DeHaney
as Hair Person
Ben Sidell
as Stage Manager
Therese Plaehn
as Autopsy Editor In Charge
Omar Ghonim
as Damian
J.O
Jody O'Neil
as Stage Manager #2
Meghan Leathers
as Media Quant
A.B
Ashleigh Banfield
as Dalia Hensfield
Sarah Silverman
as Sarah Benterman
Richard Snee
as Senator Lerner
D.W
Darryl Wooten
as FBI Agent
D.W
Danielle Waxman
as College Girl
J.S
Jeffrey Smith
as Blind Man FBI Agent
Jon Glaser
as Meow Man
Dorothy Dwyer
as Old Tough Lady
O.S
Odis Spencer
as Chief Justice
S.N
Sarah Nolen
as Sammy Puppeteer
Alvin Keith
as Harrison Telms
A.P
Alaina Pinto
as American Reporter
Lizzie Short
as French Reporter
J.L
Juri Love
as Japanese Reporter
Sujoy De
as Hindi Reporter
B.G
Brahms Guignard
as Haitian Reporter
S.B
Sergei Bushmanov
as Russian Reporter
Lewis D. Wheeler
as Mission Coordinator
Steve Gagliastro
as Onlooker
David J. Curtis
as Guy
Kevin Craig West
as Secretary of State
A.W
Alison Weller
as Secretary of Education
Rob Lévesque
as Secretary of Interior
S.Z
Sam Zephir
as Captain
Dee Nelson
as Dr. Lisa Inez
B.A
Beau Allen
as Dr. Talcamont
Rebecca Gibel
as Waitress
Brian Faherty
as Guy from the Bar
Celeste Oliva
as Nearby Diner
A.C
Amanda Cass
as Rioting Patron
Roman Mitichyan
as Rioting Patron
P.M
Paul Marini
as Rioting Patron
Alex Huynh
as Rioting Patron
Michael Jibrin
as Federal Agent
Bill Mootos
as Federal Attorney
Patti Tippo
as French President
A.B
Allyn Burrows
as Mr. Dibiasky
T.L
Tori Davis Lawlor
as Mrs. Dibiasky
J.L
Joy Lang
as Housewife
J.H
June Holmes
as Girl in Commercial
G.H
Graham Holmes
as Boy in Commercial
J.S
Jacob Sanditen
as Yule's Friend
A.M
Anthony Marrese
as Other Friend
Caroline Bergwall
as Teen Girl Friend
A.W
Anania Williams
as Short Guy Friend
Nate Richman
as Stocky FBI Agent
Wes Johnson
as Don't Look Up'er
John Bucy
as Don't Look Up'er
P.G
Patrick Gover
as Don't Look Up'er
C.P
Conrad Perry
as Don't Look Up'er
M.R
Matt Rouillard
as Don't Look Up'er
C.D
Christopher Deschenes
as Don't Look Up'er
Patrick Michael Strange
as Just Look Up'er
J.A
J.P. Aaron
as Just Look Up'er
D.A
Daniela August
as Just Look Up'er
N.S
Nicholai Senat
as Puppet Show Kid
A.Z
Alexandra Zilch
as Puppet Show Kid
J.K
Jonathan Kobs
as Truthslinger303
Bianca de la Garza
as Entertainment Journalist
C.I
Caitlin Ishibashi
as DJ at Concert
C.D
Claire Davis
as Bass Player
E.P
Elder Isaiah Perez
as Organ Player
C.H
Coran Spardakis Henley
as Drummer
L.N
Lance Norris
as Loyal Supporter
R.S
Ralph M. Studley
as Kid Rock Body Double
Frank Ridley
as Flight Director
A.H
Andrew Haserlat
as Mission Tech
J.M
Jayne McLendon
as Command Tech
Ishaan Khatter
as Raghav Manavalan
K.R
Khaldoun Rajeh
as Egyptian Family
S.R
Sheren Rajeh
as Egyptian Family
K.R
Khaled Rajeh
as Egyptian Family
K.R
Kareem Rajeh
as Egyptian Family
A.R
Ahmad Rajeh
as Egyptian Family
A.R
Adila Rajeh
as Egyptian Family
J.T
J.T. Turner
as Old Billionaire
E.P
Ed Peed
as Lobbyist
Zach Holmes
as #LaunchChallenge MeTuber (uncredited)
Chris Evans
as Devin Peters (uncredited)
Marissa Carpio
as Reporter with Big Hair (uncredited)
