Hugh Jackman

as Gabriel Van Helsing (voice)

Robbie Coltrane

as Mr. Hyde (voice)

David Wenham

as Carl (voice)

Grey DeLisle

as First Victim (voice)

Dwight Schultz

as Dr. Jekyll (voice)

John DiMaggio

as Coachman (voice)

Scott Mosenson

as Palastwache (voice)

Alun Armstrong

as Cardinal Jinetta (voice)

Roger L. Jackson

as Gentleman (voice)

Julia Fletcher

as Lady (voice)

Tress MacNeille

as Queen Victoria (voice)

Tara Strong

as Young Victoria (voice)

James Arnold Taylor

as Narrator (voice)