Jim Conroy

as Quincy Magoo (voice)

Dylan Sprouse

as Justin Magoo (voice)

Cole Sprouse

as Brad Landry (voice)

Alyson Stoner

as Lorelei Tan Gu (voice)

Chris Parnell

as Cole Fusion / Ninja (voice)

Kenny Mayne

as Kenny Mayne (voice)

Jeff Bennett

as Sid / Guard / Evil Mustache Cabal (voice)

Rodger Bumpass

as General Smith / Driver / Mastermind (voice)

Maile Flanagan

as Aliga-Tory / Orangu-Tammy (voice)

Lloyd Floyd

as Tan Gu (voice)

Jennifer Hale

as Leslie Destructo / Agent L / Dutch Boy (voice)

Tom Kenny

as Dr. Malicio / Soldier (voice)

Ryan Bollman

as Corporal Hayes / Biker (voice)

Candi Milo

as Gor-Illiana / McBarker / Sid's Mom (voice)

April Stewart

as Weas-Elizabeth / Girl with Phone (voice)

Jim Ward

as General Bonkopp / Movie Announcer / Voice on Radio (voice)

Susan Boyajian

as (voice)

Bob Joles

as (voice)

Hope Levy

as (voice)

Michael Stanton

as (voice)

Rob Tinkler

as (voice)

Fred Travalena

as (voice)

Wally Wingert

as (voice)