Dermot Mulroney

as Dante (voice)

James Cromwell

as Virgil (voice)

Olivia D'Abo

as Beatrice (voice)

Martha Plimpton

as Celia / Lobbyist Singer / Lizzie Borden (voice)

Tony Abatemarco

as Lying Defendant / Farinata (voice)

Scott Adsit

as Judge Minos / Paolo / Hirohito / Copter Pilot (voice)

Matt Besser

as Metallica Defendant / L. Ron Hubbard (voice)

Bill Chott

as Giaccio 'El Gordo' / Calvacanti / Stalin (voice)

Andy Daly

as Lucan / 'Right On' Glutton / Jim Jones / Airport Screener / Ulysses' Naysayer (voice)

Tony Hale

as Ovid / Real Estate Broker / Pope Nicholas 3rd (voice)

Tom Hallick

as George Sanders / Lobbyist (voice)

Janet Varney

as Teacher / Cleopatra / City of Dis Intercom / Ulysses' Usher (voice)

Paul Zaloom

as Homer / God / Officer Chiron / Southern Lobbyist / Airport Security / Caiaphas / Ulysses' Crew / Macmud / Insider Trader #1 / Nicole Ceausescu / Lucifer (voice)

Mike Coleman

as Charon / Phlegyas / Senator / Dick Cheney (voice)

Brandon Johnson

as Irate Driver / Mounted Policeman / Pimp #1 / Pimp #3 / Airport Security (voice)

Matt Walsh

as Mussolini / Fox Reporter / Airport Security Pursuer (voice)