Katy Perry

as Smurfette (voice)

Hank Azaria

as Gargamel

Neil Patrick Harris

as Patrick Winslow

Jayma Mays

as Grace Winslow

Brendan Gleeson

as Victor Doyle

Jacob Tremblay

as Blue Winslow

Nancy O'Dell

as Nancy O'Dell

Karim Babin

as Room Service Waiter

Gaston Morrison

as New York Taxi Driver

Jocelyn Blanchard

as Toad Man

Erika Rosenbaum

as Pregnant Mom

Carolina Bartczak

as Peanut Mom

James A. Woods

as Peanut Father

Henri Pardo

as Father-to-Be

Vanessa Matsui

as Mother with Camera

Dusan Dukic

as Curious Dad

Ruth Chiang

as Single Mom

Andy Quesnel

as Woman in Box

Mylène Dinh-Robic

as Hotel Assistant Manager

Martin-Guy Bélanger

as Hotel Sous-chef

Robert Reynaert

as Candy Man

Patrick Sabongui

as Candy Man

Martin St-Antoine

as Tourist with Coffee Cup

Patrick Baby

as Palais Garnier Security Guard

Joshua Spreekmeester

as Peanut Kid

Bruno Paviot

as Hotel Desk Manager

Gunther Love

as Cat Man in Audience

Gaëlle Pietri

as Pregnant Model

Janicke Askevold

as Pregnant Model

Beatrice Rosen

as Pregnant Model

Mathilde Snodgrass

as Pregnant Model

Mr. Krinkle

as Azrael

Hank

as Elway

Christina Ricci

as Vexy (voice)

Jonathan Winters

as Papa Smurf (voice)

JB Smoove

as Hackus (voice)

George López

as Grouchy Smurf (voice)

Anton Yelchin

as Clumsy Smurf (voice)

John Oliver

as Vanity Smurf (voice)

Frank Welker

as Azrael (voice)

Tom Kane

as Narrator Smurf (voice)

Fred Armisen

as Brainy Smurf (voice)

Jeff Foxworthy

as Handy Smurf (voice)

Alan Cumming

as Gutsy Smurf (voice)

Gary Basaraba

as Hefty Smurf (voice)

Adam Wylie

as Panicky Smurf (voice)

Joel McCrary

as Farmer Smurf (voice)

Kenan Thompson

as Greedy Smurf (voice)

Kevin Lee

as Party Planner Smurf (voice)

Paul Reubens

as Jokey Smurf (voice)

Shaquille O'Neal

as Smooth Smurf (voice)

B.J. Novak

as Baker Smurf (voice)

Jimmy Kimmel

as Passive-Aggressive Smurf (voice)

Shaun White

as Clueless Smurf (voice)

Mario López

as Social Smurf (voice)

John Kassir

as Crazy Smurf (voice)

Sean Kenin

as Smurf Voice #1 (voice)

Patricia Summersett

as Smurf Voice #2 (voice)