E. G. Daily

as Tommy Pickles (voice)

Christine Cavanaugh

as Chuckie Finster (voice)

Kath Soucie

as Phil DeVille / Lil DeVille / Betty DeVille (voice)

Cree Summer

as Susie Carmichael / Edwin Carmichael (voice)

Dionne Quan

as Kimi Finster (voice)

Ron Glass

as Randy Carmichael (voice)

Irma P. Hall

as Aunt T. (voice)

Crystal Scales

as Buster Carmichael (voice)

Hattie Winston

as Lucy Carmichael / Lucy's Mom (voice)

Kimberly Brooks

as Young Lucy (voice)

Bill Cobbs

as Uncle Charles (voice)

Erv Immeman

as Radio Announcer (voice)

Kevin Michael Richardson

as Martin Luther King Jr. (voice)

Cynthia Kaye Hunt

as Choir Soloist (voice)

Joe Alaskey

as Grandpa Lou Pickles (voice)

Sam Saletta

as Additional Voices (voice)

Bettina Bush

as Alisa Carmichael (voice)