E. G. Daily

as Tommy Pickles (voice)

Christine Cavanaugh

as Chuckie Finster (voice)

Cheryl Chase

as Angelica Pickles (voice)

Tara Strong

as Dil Pickles / Mariko (voice)

Kath Soucie

as Phil DeVille / Lil DeVille (voice)

Cree Summer

as Susie Carmichael / Edwin Carmichael (voice)

Joe Alaskey

as Grandpa Lou Pickles / Announcer (voice)

David Eccles

as Reptar / Dactar / Robot Reptar (voice)

Michael Donovan

as Evil Scientist / Jim Hashimato (voice)

Jess Harnell

as Jingle Singer (voice)

Freda Foh Shen

as Pam (voice)

Gedde Watanabe

as Zack (voice)

Joey Wilcots

as Buster Carmichael (voice)

Michael Keenan

as Professor (voice)