Mike Birbiglia

as Matt

Lauren Ambrose

as Abby

James Rebhorn

as Frank

Carol Kane

as Linda

Cristin Milioti

as Janet

Aya Cash

as Hannah

Marylouise Burke

as Aunt Lucille

Loudon Wainwright III

as Uncle Max

Ben Levin

as Philip

Henry Phillips

as Henry

Jessi Klein

as Lynn

Emily Meade

as Samantha

Danny Borbon

as Tommy

Amanda Perez

as Tammy

Lucy DeVito

as Hilary

Kristen Schaal

as Cynthia

Alex Karpovsky

as Ian

Ron Nakahara

as Ron

Wyatt Cenac

as Chris

Ira Glass

as Wedding Photographer

Marc Maron

as Marc

David Wain

as Pete

Teddy Cañez

as Pedro

William C. Dement

as Dr. Dement

Raymond Anthony Thomas

as Dr. Regan

Amy Schumer

as Amy

Sondra James

as Colleen

Alberto Bonilla

as Wedding Planner

John Lutz

as Chip

Philip Ettinger

as Doug

Jason Selvig

as Dave

Azhar Khan

as Tow Truck Driver

Angelic Zambrana

as Melissa

Meena Nerurkar

as Realtor

Edward James Hyland

as General

Chike Johnson

as Lieutentant

Alan Wilkis

as Guitar Strumming Emcee

James Creque

as Interviewer

Santos Morales

as Large Adult Man

James Fauvell

as Towel Guy In Elevator

Chavez Ravine

as Cleaning Lady

Kevin Barnett

as Union Hall Comic

Chris Cantwell

as Overzealous Student