Matthew Lillard

as Shaggy Rogers (voice)

Thea White

as Muriel Bagge / Rich Old Lady (voice)

Grey DeLisle

as Daphne Blake / Frau Glockenspiel (voice)

Frank Welker

as Scooby-Doo / Fred Jones (voice)

Kate Micucci

as Velma Dinkley (voice)

Jeff Bennett

as The General / Self Help Book (voice)

Paul Schoeffler

as Katz / Le Quack / Narrator (voice)

Marty Grabstein

as Courage / Mr. McGill (voice)

Jeff Bergman

as Eustice Bagge / Computer / Mayor of Nowhere (voice)

Chuck Montgomery

as The Lieutenant / Mr. Glockenspiel (voice)