Robert De Niro

as Don Griffin

Diane Keaton

as Ellie Griffin

Ben Barnes

as Alejandro 'Alex' Soto Griffin

Amanda Seyfried

as Missy O'Connor

Susan Sarandon

as Beatrice 'Bebe' McBride

Katherine Heigl

as Lyla Griffin

Topher Grace

as Jared Griffin

Christine Ebersole

as Muffin O'Connor

David Rasche

as Barry O'Connor

Patricia Rae

as Madonna Soto

Ana Ayora

as Nuria Soto

Robin Williams

as Father Monaghan

Kyle Bornheimer

as Andrew

Christa Campbell

as Kim

Megan Ketch

as Jane

Ian Blackman

as Maitre d'

Shana Dowdeswell

as Waitress

Doug Torres

as Waiting Father

Marvina Vinique

as Mother

Joshua Nelson

as Worker

Quincy Dunn-Baker

as Kevin

Sylvia Kauders

as Elderly Wife

Edmund Lyndeck

as Elderly Husband

John V. Barbieri

as Wedding Guest