John Travolta

as James

Kirstie Alley

as Mollie

Olympia Dukakis

as Rosie

Elias Koteas

as Stuart

Twink Caplan

as Rona

Bruce Willis

as Mikey (voice)

Roseanne Barr

as Julie (voice)

Damon Wayans

as Eddie (voice)

Gilbert Gottfried

as Joey

Mel Brooks

as Mr. Toilet Man (voice)

Lorne Sussman

as Mikey

Megan Milner

as Julie (1 year)

Georgia Keithley

as Julie (4 months)

Nikki Graham

as Julie (newborn)

Danny Pringle

as Eddie

Neal Israel

as Mr. Ross

Lesley Ewen

as Debbie

Noelle Parker

as Woman Client

Douglas Warhit

as Man Client

Terry David Mulligan

as IRS Inspector

Paul Shaffer

as Taxi Businessman

Don S. Davis

as Dr. Fleischer

Morris Panych

as Arrogant Businessman

Alex Bruhanski

as Needle Doctor

Dorothy Fehr

as Blonde

Heather Lea Gerdes

as Hot Babe on Fire Escape

Robin Trapp

as Cool Chick

Rick Avery

as Burglar

Stephen Dimopoulos

as Fire Chief

Jimmy Galeota

as Punk Baby

Frank Totino

as Candy Man

Coleman Lumley

as Blonde Baby

Constance Barnes McCansh

as Sexy Dancer

Ruby J. Munro

as Businessman's Babe

Mollie Heckerling

as Mikey's Dream Friend

Alicia Mizel

as Slob Child

Denis Corbett

as Cop (uncredited)

Yolanda Corbett

as Shopper (uncredited)